Endocrine Abstracts

Introduction: Hypothalamic-pituitary-adrenal axis dysfunction (HPA) has been reported in patients with schizophrenia and bipolar disorders but findings are inconsistent and few studies have conducted direct comparaisons of HPA biomarkers in drug native patients. We aimed to assess serum and salivary cortisol in the morning in drug-naive schizophrenic patients compared to controls.Methods: This was a cross-sectional case-control study conducted between Ju...

Introduction: Pheochromocytoma occurs in 0.1–5.7% of patients with Neurofibromatosis type 1(NF1). We report two cases of adrenal pheochromocytoma in patients with NF1.Observation: A 46 year-old male was admitted to our department for further examinations of an adrenal mass. The CT-scan showed two well-defined right adrenal masses measuring each 128×87×86 mm and 60×52×37 mm with central necrosis and calcifications in the biggest o...

Introduction:: The association of breast cancer and neuroendocrine tumours, in particular pheochromocytoma, is rarely described in the literature. We report a case in a particular context.Observation: This is a 53-year-old patient treated with 6 courses of chemotherapy for T2N3cM0 infiltrating breast carcinoma. She was admitted to our endocrinology department for exploration of a left adrenal incidentaloma, objectified in the extension assessment, measur...

Introduction: Prolactinoma is the most common secretory pituitary adenomas. It has clinical and biological characteristics that depend on age, gender and tumor size. Prolactinoma of the old subject is a rare clinical form that was not sufficiently treated in the literature.Materiels and methods: It is a retrospective study including 77 cases of prolactinoma among which 3 cases aged over than 65 years. The collection of data was made between 2000 and 2017...

Introduction: The pituitary stalk is the target of various congenital or acquired pathologies. In this context we report a cohort of 28 patients with pathology of the pituitary stalk to analyze their clinical, hormonal and radiological characteristics.Results: The average age of our patients was 28 years with extremes ranging from (15 to 64); Male dominance was noted in 60% of cases. The reason for consultation was either a staturo delay or a pubertal de...

Introduction: Infertility is a classic consequence of prolactinoma in women. The treatment of hyperprolactinemia allows the restoration of ovulatory cycles and therefore of fertility in 80–90% of cases.Methods and materials: The study is a retrospective cohort study done over 17 years from 2000 to 2017. It includes 77 cases of prolactinomas among which 12 women had one or more pregnancies after the diagnosis of prolactinoma.Re...

Introduction: Autoimmune polyglandular syndrome (APS) is an autoimmune disorder that affects many endocrine glands. Until now four categories of APS are identified: APS-I includes at least two out of: mucocutaneous candidiasis, hypoparathyroidism and adrenocortical failure. APS-II, the most frequent, comprises of Addison’s disease, autoimmune thyroid disease and/or type 1 diabetes. APS-III is defined by the presence of autoimmune thyroid disease and other autoimmune disor...

Introduction: The quality of assay methods for HbA1c assessment has importantly improved last decades, however analytical interferences due to variants of hemoglobin remain of matter vigilance. Immunological interferences, although no longer described, may also occur.Observation: A 84-years-old woman without significant medical history was explored for polyneuropathy. Additional investigation as HbA1c was requested. As no value of HbA1c was obtained when...

Introduction: Turner syndrome (ST) affects 1/2500–1/4000 of female births, its association with congenital malformations is traditional, however the coexistence of hypopituitarism is exceptional. In this context, we report 6 patients; including 3 belonging to the same family and in whom the association of anterior pituitary insufficiency (IAH) to a ST was confirmed.Results: The average age of our patients was 17.2 years (11–31). The ST was sele...

IntroductionTriple-A syndrome, also known as Allgrove syndrome, is a rare autosomal recessive disorder. It is a multisystemic disease with an estimated prevalence of 1 per 1 000 000 individuals The 3 features of this syndrome are achalasia, adrenal insufficiency, and alacrima. Recently, dental impairment has been the subject of several case reports and reviews. However, this abnormality remains under-diagnosed.Purpose<p class="...